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VASCEPA is the first and only agent studied on top of statins reported to exhibit coronary plaque regression in hypertriglyceridemic patients. As referenced below, these final results can be found in the concurrent publication in European Heart Journal. Patients underwent an interim scan at 9 months and a final scan at 18 months. The prespecified primary endpoint was a comparison of change in LAP volume at 18 months between icosapent ethyl and placebo.
There were significant differences between icosapent ethyl and placebo at study end for secondary endpoints of other types of plaque volume changes, including and sequentially total, total non-calcified, fibrofatty, and fibrous plaque volumes. The mineral oil placebo, used for consistency with REDUCE-IT, was also analyzed against plaque changes from baseline in another placebo in a separate study.
Rates of plaque changes in patients randomized to mineral oil the placebo cohort in the EVAPORATE study were compared with rates of plaque changes in the placebo arm of a second study that used a cellulose-based placebo. There was no difference in plaque progression between mineral oil and cellulose based placebos. Limitations of this single study include a small sample size.
More study is needed to demonstrate the effects of VASCEPA on coronary plaque to determine the relationship of such effects, if any, on cardiovascular risk reduction.
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RARITAN, NJ – Change was the buzz word at the August Raritan council meeting, with some minor shifts in policy, procedure and amenities that were approved, along with some major additions to the government structure. Currently, borough parks are closed, but there are no ropes or gates up to keep people out. Councilman Pablo Orozco said he has driven by and kids are playing in the parks and even drinking from the water fountains. Bray suggested opening the parks and putting swings back up, but not basketball hoops because that is often a group sport.
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